The KLE University was established on 13th April, 2006 as per the Ministry of Human Resource Development, Government of India, Notification No.F.9-19/2000-U-R(A) dated 13th April, 2006,   under the recommendation of University Grants Commission.

 Today the KLE University within three years of its inception has many glorious credentials in the form of its meritorious students, faculty looked upon as peer and much international collaboration because of the dedication and the unending quest for excellence true to the essence of KLE University.
The University offers various Undergraduate, Postgraduate, Post doctoral, fellowship and certificate programs in the faculties of Medicine, Dentistry, Pharmacy, Ayurveda, Physiotherapy and Nursing. The campus is very rich and vibrant in terms of having impressive infrastructure, renowed and extensively experienced teaching faculty, state of the art teaching hospital and medical research center, having 1820 beds and top notch diagnostic facilities under one roof. The Wi-Fi and digital library, e-learning and other facilities are at par with best campuses of the country and abroad. The University is among very few institutions of the country to boast of the entire campus having Wi-Fi solution for internet access. Another mile stone achieved is the collaboration with MedRC and establishment of Smart Teach server for students to access the high quality E-curricular content so that students can learn at their own pace as supplementary measure to the excellent classroom teaching.

 
Ever since the establishment of the University there has been constant growth in exploring the new areas in education e.g. the establishment of the institute of Public Health, Institute of Clinical Research, School of Music starting need based fellowship programs in various specialties and the commencement of Ph.D program in health facilities and inter disciplinary research are the new endeavors of the University in the short span of three years of its existence. The existing curriculum is strengthened by integrating Information and Communication Technology (ICT) to meet the changing global demands. University has also incorporated teaching of Indian Constitution and Environmental Studies to Undergraduate students for making them responsible global citizens. To match the concept of Global village of the present era the KLE University has signed Memorandum of Understandings (MoUs) incorporating academic collaborations with ICMR, W.H.O; and several Universities in USA and also in SE Asia.